1975, Olney JW, Aspartame as a Sweetener. NEJM 1975;292(23):1244-1245., Funded by: Washington University |
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1977, Mishiro Y and Keneko H, Effect of a Dipeptide, Aspartame, on Lactic Acid
Production in Human Whole Saliva. J Dent Res 1977;56(11):1427., Funded by: Nippon Dental
University, Tokyo |
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1979, Brunner RL, Vorhees CV, Kinney L, Butcher RE, et al., Aspartame:
Assessment of Developmental Psychotoxicity of a New Artificial Sweetener.
Neurobehavioral Toxicology 1979;1:79-86., Funded by: USFDA |
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1980, Olney, Brain Damage in Mice from Voluntary Ingestion of Glutamate and
Aspartate. Neurobehavioral Toxicology and Teratology 1980;2:125-129., Funded by: Washington University |
✔ |
1982, Uribe, Potential Toxicity of a New Sugar Substitute in Patients with Liver
Disease. N Engl J Med 1982;173-174., Funded by: Institute National
De La Nutrition
Mexico |
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1983, Wurtman, Effects of Aspartame and Glucose on Rat Brain Amino Acids and
Serotin. New England Journal of Medicine 1983;309(7):429-430., Funded by: M.I.T. |
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1983, Wurtman RJ, Neurological Changes Following High Dose Aspartame with
Dietary Carbohydrates. N Engl J Med 1983;309(7):429-430., Funded by: M.I.T. |
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1984, Olney, Excitotoxic Food Additives Relevance of Animal Studies to Human
Safety. Neurobehavioral Toxicology and Teratology 1984;6:455-562., Funded by: Research
Scientist
Award
MH-38894 |
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1984, Monte, Aspartame: Methanol and the Public Health. J Appl Nutr 36(1):42-54., Funded by: Arizona
State
University |
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1984, Yokogoshi H,k Roberts CH, Canballero B, Wuetman RJ, Effects of Aspartame
and Glucose Administration on Brain and Plasma Levels of Large Neutral
Amino Acids and Brain 5-Hydroxyindoles. Amer J Clin Nutr 1984;40:1-7., Funded by: M.I.T. |
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1984, Mahalik MP and Gautieri RF, Reflex Responsiveness of CF-1 Mouse Neonates
Following Maternal Aspartame Exposure. Research Communications in
Psychology, Psychiatry & Behavior 1984;9(4):385-403., Funded by: None Specified |
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1985, Novick, Aspartame Induced Granulomatous Panniculitis. Ann Int Med
102(2):206-207., Funded by: Mt. Sinai Medical
Center |
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1985, Grobelny D and Galardy RE, A Metabolite of Aspartame Inhibits Angiotensin
Converting Enzyme. Biochemical and Biophysical Research Communications,
1985; 128(2):960-964., Funded by: University of
Kentucky |
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1985, Wurtman, RJ, Aspartame: Possible Effects on Seizure Susceptibility. Lancet
1985;2(8463):1060., Funded by: M.I.T. |
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1985, Ferguson JM, Interaction of Aspartame and Carbohydrates in an Eating
Disordered Patient. Am J Psych 1985 Feb;142(2):271., Funded by: None |
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1986, Kulczycki A Jr., Aspartame Induced Urticaria. Ann Intern Med
1986;104(2):207-208., Funded by: N.I.H. |
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1986, Pardridge WM, The Safety of Aspartame [Letter]. JAMA 1986;256(19):2678., Funded by: UCLA School of
Medicine |
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1986, Koehler SM, A New Dietary Caution for Migraine Sufferers. Dir in Appl Nut
1986;1:1-7., Funded by: Center for
Brain Sciences
and Metabolism
U of FL.
|
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1986, Kiritsky PJ and Maher TJ, Acute Effects of Aspartame on Systolic Blood
Pressure in Spontaneously Hypertensive Rats. J Neural Transmission
1986;66(2):121-128., Funded by: National
Institute of
Neurological,
Communicative
Diseases and
Stroke |
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1986, Yokogoshi H and Wurtman RJ, Acute Effects of Oral or Parenteral Aspartame
on Catecholamine Metabolism in Various Regions of Rat Brain. J Nutr
1986;116:356-364., Funded by: M.I.T. |
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1986, Walton, Seizure and Mania After High Intake of Aspartame. Psychosomatics
27:218-220., Funded by: Chautauqua
County Dept of
Mental Health |
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1986, Drake ME, Panic Attacks and Excessive Aspartame Ingestion [Letter]. Lancet
1986;2(8507):631., Funded by: None |
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1986, Johns DR, Migrane Provoked by Aspartame. New Eng J Medicine
1986;315(7):456., Funded by: None |
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1986, Blundell JE, Hill AJ, Paradoxical Effects of an Intense Sweetener Aspartame on
Appetite. Lancet 1986;1(8489):1092-3., Funded by: None |
✔ |
1986, Caballero B, Mahon BE, Rohr FJ, Levy HL, Wurtman RJ, et. al., Plasma
Amino Acid Levels after Single Dose Aspartame Consumption in
Phenylketonuria Mild Hyperphenylalaninemia and Heterozygous State for
Phenylketonuria. Journal of Pediatrics 1986;109(4):668-671., Funded by: National Institute
of Neurological,
Communicate
Diseases and
Stroke |
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1986, Bradstock MK, Serdula MK, Marks IS, et al., Evaluation of Reactions to Food
Additives: The Aspartame Experience. AM J Clin Nutr 1986 Mar;43(3):464-9., Funded by: Federal
Government |
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1986, Coulombe RA Jr., Sharma RP, Neurobiochemical Alterations Induced by the
Artificial Sweetener Aspartame. Toxicol Appl Pharmacol 1986;83(1):79-85., Funded by: Utah State
University |
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1987, Wurtman RJ, Aspartame Effects on Brain Serotonin. Am J Clin Nutr 1987
Apr;45(4):799-803., Funded by: M.I.T. |
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1987, Maher TJ and Wurtman RJ, Possible Neurologic Effects of Aspartame, a
Widely Used Food Additive. Environmental Health Perspectives 1987;75:53-57., Funded by: M.I.T. & Federal
Government |
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1987, Drogari E, Smith I, Beasley M, Lloyd JK, Timing of Strict Diet in Relation to
Fetal Damage in Maternal Phenylketonuria: An International Collaborative
Study by the MRC/DHSS Phenylketonuria Register. Lancet 1987;2(8565):927-30., Funded by: Institute of Child
Health |
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1987, Elsas, et al., Changes in Physiological Concentrations of Blood Phenylalanine
Produce Changes in Human Brain Function. Dietary Phenylalanine and Brain
Function Birkhauser Boston 1988;187-195., Funded by: Emory University |
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1988, Roberts: Neurological, Psychiatric and Behavioral Reactions to Aspartame in
505 Aspartame Reactors. In: Wurtman and Ritter-Walker (eds.). Dietary
Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 373-376., Funded by: Palm Beach
Institute for
Medical Research |
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1988, Pinto and Maher, Aspartame, Phenylalanine and Seizures in Experimental
Animals. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine and
Brain Function. Boston: Birkhauser, 1988, pp. 95-103., Funded by: National Institute
of Neurological
and
Communicative
Diseases and
Stroke |
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1988, Roberts, Reactions Attributed to Aspartame Containing Products: 551 Cases.
Journal of Applied Nutrition 1988;40:85-94., Funded by: Palm Beach
Institute for
Medical Research |
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1988, Roberts, Neurological Psychiatric and Behavioral Reactions to Aspartame in
505 Aspartame Reactors. In: Wurtman and Ritter-Walker (eds.). Dietary
Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 373-376., Funded by: None |
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1988, Wurtman and Maher, Calculation of the Aspartame Dose for Rodents that Produces Neurochemical Effects Comparable to Those Occurring in People. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 144-148., Funded by: M.I.T. |
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1988, Pinto JM, Mahea TJ, Administration of Aspartame Potentiates
Pentylenetetrazole and Fluorothyl-Induced Seizures in Mice.
Neuropharmacology 1988;27(1):51-55., Funded by: Massachusetts
College of
Pharmacy |
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1988, Walton, The Possible Role of Aspartame in Seizure Induction. Proceedings of
the first International Conference on Phenylalanine and the Brain. Wurtman RJ,
Walker E (eds.), Center for Brain Sciences and Metabolism Charitable Trust,
Cambridge, 1987., Funded by: Chautauqua
County Dept of
Mental Health |
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1988, Tollefson L, Monitoring Adverse Reactions to Food Additives in the US Food
and Drug Administration. Regulatory Toxicology and Pharmacology
1988;8(4):438-446., Funded by: FDA |
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1988, Olney, Excitotoxic Food Additives Functional Teratological Aspects. In
Progress in Brain Research, Vol 73 Biochemical Basis of Functional
Neuroteratology: Permanent Effects of Chemical on the Developing Brain,
edited by Boer, GJ, et al., Elsevier, New York 1988., Funded by: Washington University |
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1988, Tollefson L, Monitoring of Adverse Reactions to Aspartame Reported to the
U.S. Food and Drug Administration. In: Wurtman and Ritter-Walker (eds.).
Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 317-326., Funded by: FDA |
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1988, Steinmetzer and Kunkel, Aspartame and Headache [letter]. N Engl J Med
1988;318(18):1201., Funded by: Cleveland Clinic |
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1988, Spiers, et al., Aspartame and Human Behavior: Cognitive and Behavioral
Observations. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine
and Brain Function. Boston: Birkhauser, 1988, pp. 169-178., Funded by: Center for Brain
Sciences and
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Charitable Trust |
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1988, Sardesai, et. al., Effect of Aspartame in Diabetic Rats. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine and Brain Function. Boston: Birkhauser,
1988, pp. 265-268., Funded by: Wayne State
University |
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1988, Matalon, et. al., Aspartame Consumption in Normal Individuals and Carriers for
Phenylketonuria. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine
and Brain Function. Boston: Birkhauser, 1988, pp. 41-52., Funded by: N.I.H. and The
University of
Illinois |
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1988, Guiso G, Caccia S, Vezzani A, et. al., Effect of Aspartame on Seizures in
Various Models of Experimental Epilepsy. Toxicology and Applied
Pharmacology 1988;96:485-493., Funded by: Istituto di
Ricerche
Farmacologiche
Mario Negri,
Via Eritrea |
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1988, Johns, Aspartame and Headache. In: Wurtman and Ritter-Walker (eds.).
Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 303-312., Funded by: Johns Hopkins
University |
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1988, Fernstrom, Effects of Aspartame Ingestion on Large Neutral Amino Acids and
Monoamine Neurotransmitters in the Central Nervous System. In: Wurtman
and Ritter-Walker (eds.). Dietary Phenylalanine and Brain Function. Boston:
Birkhauser, 1988, pp. 87-96., Funded by: N.I.M.H. |
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1988, Maher and Kiritsy, Aspartame Administration Decreases the Entry of Alpha-Methyldopa into the Brain of Rats. In: Wurtman and Ritter-Walker (eds.).
Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 122-126., Funded by: Massachusetts
College of
Pharmacy |
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1988, Elsas, Aspartame and Migraine. N Engl J Med 1988;318(18):1201., Funded by: Emory University |
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1988, Kim, et al., The Effect of Aspartame on 50% Convulsion Doses of Lidocaine.
In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine and Brain
Function. Boston: Birkhauser, 1988, pp. 127-130., Funded by: Indiana University
and Ball State
University |
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1988, Blundell, Effects of Aspartame on Appetite and Food Intake. In Dietary
Phenylalanine and Brain Function, Wurtman and Ritter-Walker, Editors,
1988;Birkhauser, Boston, 275-295., Funded by: University of
Leeds |
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1988, Lipton RB, Newman LC, Cohen JS, Solomon S, Aspartame and Headache.
The New England Journal of Medicine 1988 May 5;1200., Funded by: Albert Einstein
College of
Medicine |
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1988, Lipton, et al., Aspartame as a Dietary Factor in Headache. Neurology
1988;38:356., Funded by: National Headache
Foundation |
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1988, Lipton, et al., Aspartame as a Dietary Trigger of Headache. Headache
1989;29(2):90-2., Funded by: National Headache
Foundation |
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1988, Koehler SM, Glaros A, The Effect of Aspartame on Migraine Headache.
Headache 1988;28:10-13., Funded by: Center for
Brain Sciences
and Metabolism
Charitable Trust &
The University of
Florida |
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1989, Potenza DD and el-Mallakh RS, Aspartame: Clinical Update. Conn Med
1989;53(7):395-400., Funded by: None |
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1989, Holder MD and Yirmiya R, Behavioral Assessment of the Toxicity of
Aspartame. Pharmacology Biochemistry and Behavior 1989;32:17-26., Funded by: N.I.H. |
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1989, Yost DA, Clinical Safety of Aspartame [Review].* AFP 1989 Feb;39(2):201-206., Funded by: University of
Arizona |
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1989, Dow-Edwards DL, Scribani LA, Riley EP, et. al., Impaired Performance on
Odor-Aversion Testing Following Prenatal Aspartame Exposure in the Guinea
Pig. Neurotoxicology and Teratology. 1989 Jul-Aug;11(4):413-416., Funded by: Laboratory
of Cerebral
Metabolism, State
University of New
York. |
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1989, Dow-Edwards DL, Scribani LA, Riley EP, Impaired Performance on Odor-Aversion Testing Following Prenatal Aspartame Exposure in the Guinea Pig.
Neurotoxicol Teratol 1989;11(4):413-6., Funded by: State University of
N.Y. |
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1989, Bresnick, Excitotoxins: A Possible New Mechanism for the Pathogenesis of
Ischemic Retinal Damage. Arch Opmalmol 1989 Mar;107(3):339-41., Funded by: N.I.H. |
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1990, Turdoff MG, and Alleva AM, Oral Stimulation with Aspartame Increases
Hunger. Physiology Behavior 1990;47(3):555-9., Funded by: None Specified |
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1990, Pan-Hou H, et. al., Effect of Aspartame on N-Methyl-D-Aspartate Sensitive L-[3H] Glutamate Binding Sites in Rat Brain Synaptic Membranes. Brain Res
1990;520(1-2):351-353., Funded by: Setsunan
University |
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1991, Strathman, Recurrent Vulvovaginitis Resulting From the Heavy Dietary Use of
Aspartame. J Reprod Med 1991 Aug;36(8):572., Funded by: No Funding |
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1991, Roberts, Does Aspartame Cause Human Brain Cancer. Journal of
Advancement in Medicine 4(4):231-241., Funded by: None |
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1991, Watts RS, Aspartame, Headaches and Beta Blockers. Headache
1991;31(3):181-2., Funded by: None |
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1991, Tilson HA, Hong JS, Sobotka TS, et. al., High Doses of Aspartame have no
Effect on Sensorimotor Function or Learning and Memory in Rats.
Neurotoxicology & Teratology 1991;13(1):27-35., Funded by: FDA |
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1991, McCauliffe DP, Poitras K, et. al., Aspartame-Induced Lobular Panniculitis. J
Am Acad Dermatol 1991;24(2 Pt 1):298-300., Funded by: U.S. Air Force |
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1991, Moller SE, Effect of Aspartame and Protein, Administered in Phenylalanine-Equivalent Doses on Plasma Neutral Amino Acids, Aspartate, Insulin and
Glucose in Man. Pharmacol Toxicol 1991;68(5):408-12., Funded by: St. Hans Hospital,
Denmark |
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1991, Diomed L, Romano M, Guiso G, et. al., Interspecies and Interstrain Studies on
the Increased Susceptibility to Metrazol-Induced Convulsions in Animals given
Aspartame. Food & Chem Toxicol 1991;29(2):101-106., Funded by: Istituto di Ricerche
Farmacologiche
Mario Negri,
Milan, Italy |
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1991, Guiso, et. al., Effect of Tyrosine on the Potentiation by Aspartame and
Phenylalanine of Metrazol-Induced Convulsions in Rats. Food Chem Toxicol
1991 Dec;29(12):855-7., Funded by: Instituto di
Ricerche
Farmacologiche
Mario Negri, Italy,
Via Eritrea |
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1992, Tollefson L and Barnard RJ, An Analysis of FDA Passive Surveillance Reports
of Seizures Associated with Consumption of Aspartame. Journal of the
American Dietetic Association 1992;92(5):598-601., Funded by: FDA |
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1992, Camfield PR, Camfield CS, Dooley JM, et. al., Aspartame Exacerbates EEG
Spike Wave Discharge in Children With Generalized Absence Epilepsy: A
Double-Blind Controlled Study. Neurology 1992;42:1000-1003., Funded by: Ontario Ministry
of Health |
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1992, Gulya AJ, Sessions RB, Troost TR, et. al., Aspartame and Dizziness:
Preliminary Results of a Prospective, Nonblinded, Prevalence and Attempted
Cross-over Study. American J of Otology 1992 Sept;13(5):438-42., Funded by: Georgetown
University |
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1993, Shephard SE, Wakabayashi K, Nagao M, et. al., Mutagenic Activity of Peptides
and the Artificial Sweetener Aspartame After Nitrosation. Food & Chemical
Toxicol 1993;31(5):323-9., Funded by: National Cancer
Center Research
Institute Japan |
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1993, Walton RG, Hudak R, Greenwaite RJ, Adverse Reaction to Aspartame:
Double-Blind Challenge in Patients from a Vulnerable Population. Biological
Psychiatry 1993;34(1-2):13-17., Funded by: Western Reserve
Care System |
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1993, Tollefson L, Multiple Chemical Sensitivity: Controlled Scientific Studies as
Proof of Causation. * Regulatory Toxicology and Pharmacology 1993;18:32-43., Funded by: FDA |
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1993, Eshel Y and Sarova-Pincus I, Aspartame and Seizures. Neurology
1993;43(10):2154-2155., Funded by: None Specified |
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1993, Kasamaki A, Uresawa S, et. al., The Effect of Food Chemicals on Cell Aging of
Human Diploid Cells in Vitro Culture. J Toxicol Sci 1993;18(3):143-53., Funded by: Sapparo Medical
College Japan |
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1993, Meldrum, Amino Acids as Dietary Excitotoxins: A Contribution to
Understanding Neurodegenerative Disorders. Brain Res Rev 1993 Sept-Dec;18(3):293-314., Funded by: Institute of
Psychiatry
London |
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1994, Van Den Eeden SK, Koepsell TD, Langstreth WT Jr, et a., Aspartame Ingestion
and Headaches: A randomized Crossover Trial. Neurology 1994;44(10):1787-93., Funded by: University of
Washington |
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1994, Stokes AF, Belger A, Banich MT, Bernadine E, et. al., Effects of Alcohol and
Chronic Aspartame Ingestion Upon Performance in Aviation Relevant Cognitive
Tasks. Aviation, Space, and Environmental Medicine 1994;65:7-15., Funded by: FDA |
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1994, Olney, Excitotoxins in Foods. Neurotoxicology 1996;15(3):535-544., Funded by: Washington University |
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1994, Gerrard JW, Richardson JS, Donat J, et. al., Neuropharmacological Evaluation
of Movement Disorders that are Adverse Reactions to Specific Foods. Int J
Neurosci 1994 May;76(1-2):61-9., Funded by: University of
Saskatchewan,
Saskatoon, Canada |
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1994, Barua J, Bal A, A Health Alert: Emerging Facts about Aspartame. Jour Diab
Assoc India 1995;35(4):92-107., Funded by: S. L. Raheja
Hospital Bombay |
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1995, Sonnewald U, Muller T, Unsgaro G, Peterson SB, et. al., Effect of Aspartame
on 45 CA Influx and LDH Leakage from Nerve Cells in Culture. Neuroreport
1995 45 CA;6(2);318-320., Funded by: Research Council
of Norway |
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1995, Kulczychi A Jr., Aspartame Induced Hives. Journal of Allergy and Clinical
Immunology 1995;95(2):639-40., Funded by: Washington University |
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1996, Roberts HJ, Aspartame as a Cause of Allergic Reactions, Including
Anaphylaxis. Arch Intern Med 1996;156(9);1027-8., Funded by: Palm Beach
Institute for
Medical Research |
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1996, Olney JW, Farber NB, Spitznagel E, Robins L, Increasing Brain Tumor Rates:
Is There a Link to Aspartame? Journal of Neuropathology and Experimental
Neurology 1996;55(11);1115-1123., Funded by: N.I.M.H. |
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1998, Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X, Fernandez-Lopez JA,
Alemany M, Formaldehyde Derived From Dietary Aspartame Binds to Tissue
Components In Vivo. Life Sciences 1998;63(5);337-349., Funded by: Universitat de
Barcelona |
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